GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs1577917 | 1 | rs10455455 | chr6:86670214 | SNHG5 | chr6:86386726-86388451:- | -0.61 | -18.58 | 5.96E-67 | Response to antipsychotic treatment |
| BRCA | cis | rs1577917 | 1 | rs10455456 | chr6:86670322 | SNHG5 | chr6:86386726-86388451:- | -0.57 | -18.17 | 1.84E-64 | Response to antipsychotic treatment |
| BRCA | cis | rs2294008 | 1 | rs1045574 | chr8:143763958 | LY6K | chr8:143781529-143785582:+ | 0.18 | 5.19 | 2.47E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BRCA | cis | rs2294008 | 1 | rs1045574 | chr8:143763958 | LYNX1 | chr8:143845758-143859640:- | -0.29 | -9.06 | 6.01E-19 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BRCA | cis | rs2294008 | 1 | rs1045574 | chr8:143763958 | PSCA | chr8:143761875-143764142:+ | 0.45 | 15.23 | 1.57E-47 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BRCA | cis | rs2294008 | 1 | rs1045574 | chr8:143763958 | SLURP1 | chr8:143822363-143823829:- | -0.18 | -6.44 | 1.77E-10 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BRCA | cis | rs12216499 | 1 | rs10455768 | chr6:159364322 | RSPH3 | chr6:159398268-159421198:- | 0.21 | 3.79 | 0.000157 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs10455769 | chr6:159374007 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.71 | 0.000216 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs10455770 | chr6:159374304 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.71 | 0.000216 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs10455772 | chr6:159396403 | RSPH3 | chr6:159398268-159421198:- | 0.22 | 4.01 | 6.55E-5 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs10455830 | chr6:159361236 | RSPH3 | chr6:159398268-159421198:- | 0.2 | 3.7 | 0.000228 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs10455832 | chr6:159364354 | RSPH3 | chr6:159398268-159421198:- | 0.21 | 3.79 | 0.000157 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs10455835 | chr6:159392353 | RSPH3 | chr6:159398268-159421198:- | 0.22 | 3.95 | 8.17E-5 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs12216499 | 1 | rs10455836 | chr6:159394754 | RSPH3 | chr6:159398268-159421198:- | 0.22 | 3.97 | 7.77E-5 | Bladder cancer (smoking interaction) |
| BRCA | cis | rs853679 | 1 | rs10456362 | chr6:28221816 | HIST1H4J | chr6:27791903-27792257:+ | 0.19 | 3.82 | 0.000143 | Depression |